منابع مشابه
Busulphan lung in childhood.
A child receiving busulphan treatment for adult-type chronic myeloid leukaemia responded well for four years before the onset of complications leading to "busulphan lung'. Pulmonary function tests (PFT) were useful in monitoring the development of this condition and we recommended regular PFT for patient receiving busulphan treatment.
متن کاملAcute leukaemia after busulphan.
During a double-blind study of two years' cytotoxic chemotherapy with busulphan or cyclophosphamide in patients who had had resection of carcinoma of the bronchus the long-term effects of these two drugs were also studied. Four of the 243 patients treated with busulphan developed leukaemia compared with none of the 234 treated with cyclophosphamide and none of the 249 on placebo. None of these ...
متن کاملStudies on Mechanisms of Busulphan Cytotoxicity and Pharmacokinetics with Special Reference to Liposomal Busulphan
Busulphan is an alkylating agent currently used in conditioning regimen prior to stem cell transplantation (SCT). High dose therapy with busulphan has been shown to contribute to transplantation-related toxicities, such as veno-occlusive disease (VOD) and interstitial pneumonia. Previous pharmacodynamic studies have attempted to define a target systemic exposure to busulphan, and thresholds for...
متن کاملLung function in patients receiving busulphan.
An attempt was made to achieve earlier detection of busulphan lung (fibrosing alveolitis) and to determine its incidence by means of serial studies during life, including measurement of the gas transfer factor. Twenty-three patients were investigated over an average period of nearly two years of busulphan treatment. One case of busulphan lung was detected and subsequently confirmed at necropsy,...
متن کاملMannitol Busulphan in Disseminated Breast Carcinoma.
Clmincal Material Patients with extensive carcinoma of the breast or prostate are referred here for consideration for hypophysectomy, which is undertaken only when disease is disseminated or when extensive inoperable local disease is present. In all, 15 patients have received mannitol busulphan; 14 of these had undergone previous hypophysectomy. Mannitol busulphan was given when evidence was ob...
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ژورنال
عنوان ژورنال: BMJ
سال: 1966
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.5489.736-d